BAIT
HSPA1L
HSP70-1L, HSP70-HOM, HSP70T, hum70t, DADB-333F21.5
heat shock 70kDa protein 1-like
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MAP3K1
MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
GO Process (17)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- actin cytoskeleton organization [IBA]
- activation of MAPKK activity [IBA, NAS]
- apoptotic process [IBA]
- cellular response to mechanical stimulus [IEP]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- protein phosphorylation [NAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID