BAIT
ICAM1
BB2, CD54, P3.58
intercellular adhesion molecule 1
GO Process (18)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [IMP]
- adhesion of symbiont to host [IDA]
- cell adhesion [IDA]
- cytokine-mediated signaling pathway [TAS]
- establishment of endothelial barrier [IGI]
- extracellular matrix organization [TAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte cell-cell adhesion [IMP]
- leukocyte migration [IEP]
- membrane to membrane docking [IEP]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cellular extravasation [IMP]
- receptor-mediated virion attachment to host cell [IDA]
- regulation of immune response [TAS]
- regulation of leukocyte mediated cytotoxicity [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FGG
PRO2061
fibrinogen gamma chain
GO Process (18)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell-matrix adhesion [IDA]
- cellular protein complex assembly [IDA]
- extracellular matrix organization [TAS]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- platelet activation [TAS]
- platelet aggregation [IDA]
- platelet degranulation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of exocytosis [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA]
- positive regulation of peptide hormone secretion [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [NAS]
- positive regulation of vasoconstriction [IDA]
- protein polymerization [IMP]
- response to calcium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID