IL10
Gene Ontology Biological Process
- B cell differentiation [NAS]
- B cell proliferation [NAS]
- cell-cell signaling [IC]
- cellular response to lipopolysaccharide [NAS]
- cytoplasmic sequestering of NF-kappaB [NAS]
- hemopoiesis [TAS]
- inflammatory response [IDA]
- leukocyte chemotaxis [TAS]
- negative regulation of B cell proliferation [IDA]
- negative regulation of MHC class II biosynthetic process [TAS]
- negative regulation of T cell proliferation [NAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of interferon-alpha biosynthetic process [NAS]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of B cell apoptotic process [IDA]
- positive regulation of JAK-STAT cascade [IBA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- receptor biosynthetic process [IDA]
- regulation of gene expression [IDA]
- regulation of isotype switching [NAS]
- response to glucocorticoid [IDA]
- response to molecule of bacterial origin [IDA]
- type 2 immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
A2M
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| A2M IL10 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID