BAIT
IL10
CSIF, GVHDS, IL-10, IL10A, TGIF, RP11-262N9.1
interleukin 10
GO Process (27)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- B cell differentiation [NAS]
- B cell proliferation [NAS]
- cell-cell signaling [IC]
- cellular response to lipopolysaccharide [NAS]
- cytoplasmic sequestering of NF-kappaB [NAS]
- hemopoiesis [TAS]
- inflammatory response [IDA]
- leukocyte chemotaxis [TAS]
- negative regulation of B cell proliferation [IDA]
- negative regulation of MHC class II biosynthetic process [TAS]
- negative regulation of T cell proliferation [NAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of interferon-alpha biosynthetic process [NAS]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of B cell apoptotic process [IDA]
- positive regulation of JAK-STAT cascade [IBA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- receptor biosynthetic process [IDA]
- regulation of gene expression [IDA]
- regulation of isotype switching [NAS]
- response to glucocorticoid [IDA]
- response to molecule of bacterial origin [IDA]
- type 2 immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
A2M
A2MD, CPAMD5, FWP007, S863-7
alpha-2-macroglobulin
GO Process (10)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Related interactions
Curated By
- BioGRID