BAIT
IL6
BSF2, HGF, HSF, IFNB2, IL-6
interleukin 6
GO Process (51)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- T-helper 17 cell lineage commitment [ISS]
- acute-phase response [TAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to lipopolysaccharide [IMP]
- cytokine-mediated signaling pathway [IDA]
- defense response to Gram-negative bacterium [IEP]
- defense response to Gram-positive bacterium [IEP]
- defense response to virus [IDA]
- endocrine pancreas development [ISS]
- glucagon secretion [ISS]
- hepatic immune response [IDA, TAS]
- humoral immune response [IC]
- inflammatory response [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- monocyte chemotaxis [IC]
- negative regulation of apoptotic process [IDA]
- negative regulation of chemokine biosynthetic process [ISS]
- negative regulation of collagen biosynthetic process [IDA]
- negative regulation of fat cell differentiation [NAS]
- negative regulation of lipid storage [NAS]
- neuron projection development [IMP]
- neutrophil apoptotic process [IDA]
- neutrophil mediated immunity [IC]
- platelet activation [TAS]
- positive regulation of B cell activation [IDA]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of STAT protein import into nucleus [IC]
- positive regulation of T cell proliferation [IDA]
- positive regulation of acute inflammatory response [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of chemokine production [IDA, IMP]
- positive regulation of immunoglobulin secretion [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of leukocyte chemotaxis [IC]
- positive regulation of osteoblast differentiation [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of translation [IDA]
- positive regulation of type B pancreatic cell apoptotic process [TAS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- regulation of angiogenesis [IC]
- regulation of vascular endothelial growth factor production [IDA]
- response to glucocorticoid [IDA]
- response to peptidoglycan [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ZBTB16
PLZF, ZNF145
zinc finger and BTB domain containing 16
GO Process (14)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [NAS]
- cartilage development [IDA]
- central nervous system development [ISS]
- hemopoiesis [IDA, TAS]
- mesonephros development [ISS]
- myeloid cell differentiation [TAS]
- negative regulation of myeloid cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, NAS]
- positive regulation of cartilage development [IDA]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of ossification [IDA]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, NAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- DNA binding [IDA, NAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID