BAIT
MMP1
CLG, CLGN
matrix metallopeptidase 1 (interstitial collagenase)
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
F2R
CF2R, HTR, PAR-1, PAR1, TR
coagulation factor II (thrombin) receptor
GO Process (45)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- STAT protein import into nucleus [IDA]
- activation of MAPKK activity [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- anatomical structure morphogenesis [TAS]
- blood coagulation [TAS]
- connective tissue replacement involved in inflammatory response wound healing [IDA]
- establishment of synaptic specificity at neuromuscular junction [ISS]
- homeostasis of number of cells within a tissue [ISS]
- inflammatory response [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of glomerular filtration [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of renin secretion into blood stream [ISS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- platelet activation [IDA, TAS]
- platelet dense granule organization [IC]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rho protein signal transduction [ISS]
- positive regulation of blood coagulation [IDA]
- positive regulation of calcium ion transport [ISS]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [ISS]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISS]
- positive regulation of interleukin-6 secretion [IDA]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of smooth muscle contraction [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vasoconstriction [ISS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISS]
- regulation of blood coagulation [IDA]
- regulation of interleukin-1 beta production [ISS]
- regulation of sensory perception of pain [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- response to lipopolysaccharide [ISS]
- response to wounding [IDA]
- tyrosine phosphorylation of STAT protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID