BAIT
PDGFRB
CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1
platelet-derived growth factor receptor, beta polypeptide
GO Process (42)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- aorta morphogenesis [ISS]
- cardiac myofibril assembly [ISS]
- cell chemotaxis [IDA]
- cell migration [IMP]
- cell migration involved in coronary angiogenesis [ISS]
- cell migration involved in vasculogenesis [ISS]
- cellular response to platelet-derived growth factor stimulus [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- metanephric glomerular capillary formation [ISS]
- metanephric glomerular mesangial cell proliferation involved in metanephros development [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol metabolic process [IMP]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-beta signaling pathway [IMP]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of calcium ion import [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [ISS]
- positive regulation of smooth muscle cell migration [IMP, ISS]
- positive regulation of smooth muscle cell proliferation [IMP, ISS]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton organization [ISS]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- smooth muscle cell chemotaxis [ISS]
Gene Ontology Molecular Function- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
STAT3
ADMIO, APRF, HIES
signal transducer and activator of transcription 3 (acute-phase response factor)
GO Process (27)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISS, TAS]
- astrocyte differentiation [ISS]
- cellular component movement [TAS]
- cellular response to hormone stimulus [IDA]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [ISS]
- eye photoreceptor cell differentiation [ISS]
- glucose homeostasis [ISS]
- growth hormone receptor signaling pathway [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [ISS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein import into nucleus [IDA]
- radial glial cell differentiation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [IDA]
- sexual reproduction [ISS]
- signal transduction [TAS]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID