BAIT
STAT1
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
signal transducer and activator of transcription 1, 91kDa
GO Process (32)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- JAK-STAT cascade [IDA]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- apoptotic process [ISS]
- blood circulation [ISS]
- cellular response to interferon-beta [IMP]
- cytokine-mediated signaling pathway [TAS]
- endothelial cell migration [IMP]
- interferon-gamma-mediated signaling pathway [IDA, ISS, TAS]
- metanephric mesenchymal cell differentiation [ISS]
- metanephric mesenchymal cell proliferation involved in metanephros development [ISS]
- negative regulation by virus of viral protein levels in host cell [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISS]
- negative regulation of metanephric nephron tubule epithelial cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of smooth muscle cell proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of apoptotic process [TAS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- renal tubule development [IMP]
- response to cAMP [ISS]
- response to cytokine [ISS]
- response to peptide hormone [ISS]
- transcription from RNA polymerase II promoter [IDA]
- tumor necrosis factor-mediated signaling pathway [IDA]
- type I interferon signaling pathway [ISS, TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- tumor necrosis factor receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- tumor necrosis factor receptor binding [IPI]
Homo sapiens
PREY
STAT5A
MGF, STAT5
signal transducer and activator of transcription 5A
GO Process (16)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [ISS]
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- allantoin metabolic process [ISS]
- citrate metabolic process [ISS]
- creatine metabolic process [ISS]
- creatinine metabolic process [ISS]
- fatty acid metabolic process [ISS]
- isoleucine metabolic process [ISS]
- oxaloacetate metabolic process [ISS]
- prolactin signaling pathway [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- succinate metabolic process [ISS]
- taurine metabolic process [ISS]
- valine metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID