BAIT
TGFB2
LDS4, TGF-beta2
transforming growth factor, beta 2
GO Process (72)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- SMAD protein import into nucleus [IDA]
- SMAD protein signal transduction [IBA]
- activation of protein kinase activity [IDA]
- angiogenesis [TAS]
- blood coagulation [TAS]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell proliferation [IDA]
- cardioblast differentiation [IDA]
- catagen [IDA]
- cell cycle arrest [IDA]
- cell death [IDA]
- cell migration [IDA]
- cell morphogenesis [IDA]
- cell proliferation [TAS]
- cell-cell junction organization [IDA]
- cell-cell signaling [TAS]
- collagen fibril organization [IDA]
- dopamine biosynthetic process [ISS]
- embryo development [TAS]
- embryonic digestive tract development [IEP]
- epithelial to mesenchymal transition [IDA, TAS]
- extracellular matrix organization [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- eye development [IDA]
- generation of neurons [TAS]
- glial cell migration [IDA]
- hair follicle development [IDA, ISS]
- hair follicle morphogenesis [ISS]
- heart development [IDA]
- heart morphogenesis [IDA]
- hemopoiesis [ISS]
- negative regulation of alkaline phosphatase activity [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of immune response [TAS]
- negative regulation of macrophage cytokine production [IDA]
- neuron development [ISS]
- neutrophil chemotaxis [ISS, TAS]
- odontogenesis [NAS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cardioblast differentiation [IDA]
- positive regulation of catagen [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell cycle [ISS]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of heart contraction [IDA]
- positive regulation of immune response [ISS]
- positive regulation of integrin biosynthetic process [IDA]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of ossification [IEP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of stress-activated MAPK cascade [IDA]
- protein phosphorylation [IDA]
- regulation of transforming growth factor beta2 production [IMP]
- response to drug [IDA]
- response to hypoxia [IMP]
- response to progesterone [IDA]
- response to wounding [IEP]
- salivary gland morphogenesis [IEP]
- signal transduction by phosphorylation [IDA]
- somatic stem cell division [ISS]
- transforming growth factor beta receptor signaling pathway [IDA]
- uterine wall breakdown [TAS]
- wound healing [ISS]
Gene Ontology Molecular Function- beta-amyloid binding [IDA]
- cytokine activity [TAS]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- receptor binding [IMP]
- receptor signaling protein serine/threonine kinase activity [IDA]
- transforming growth factor beta receptor binding [IDA]
- type II transforming growth factor beta receptor binding [IDA, IPI]
- beta-amyloid binding [IDA]
- cytokine activity [TAS]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- receptor binding [IMP]
- receptor signaling protein serine/threonine kinase activity [IDA]
- transforming growth factor beta receptor binding [IDA]
- type II transforming growth factor beta receptor binding [IDA, IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
APP
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- axon cargo transport [ISS]
- axon midline choice point recognition [ISS]
- axonogenesis [ISS]
- blood coagulation [TAS]
- cellular copper ion homeostasis [ISS]
- collateral sprouting in absence of injury [ISS]
- dendrite development [ISS]
- endocytosis [ISS]
- extracellular matrix organization [ISS, TAS]
- innate immune response [TAS]
- ionotropic glutamate receptor signaling pathway [ISS]
- locomotory behavior [ISS]
- mRNA polyadenylation [ISS]
- mating behavior [ISS]
- negative regulation of endopeptidase activity [IDA]
- neuron apoptotic process [IMP]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of mitotic cell cycle [ISS]
- protein phosphorylation [ISS]
- regulation of epidermal growth factor-activated receptor activity [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of synapse structure or activity [ISS]
- regulation of translation [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISS]
- axon [ISS]
- cell surface [IDA]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [ISS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- nuclear envelope lumen [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule lumen [TAS]
- receptor complex [IDA]
- synapse [IDA]
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID