BAIT
TGFB2
LDS4, TGF-beta2
transforming growth factor, beta 2
GO Process (72)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- SMAD protein import into nucleus [IDA]
- SMAD protein signal transduction [IBA]
- activation of protein kinase activity [IDA]
- angiogenesis [TAS]
- blood coagulation [TAS]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell proliferation [IDA]
- cardioblast differentiation [IDA]
- catagen [IDA]
- cell cycle arrest [IDA]
- cell death [IDA]
- cell migration [IDA]
- cell morphogenesis [IDA]
- cell proliferation [TAS]
- cell-cell junction organization [IDA]
- cell-cell signaling [TAS]
- collagen fibril organization [IDA]
- dopamine biosynthetic process [ISS]
- embryo development [TAS]
- embryonic digestive tract development [IEP]
- epithelial to mesenchymal transition [IDA, TAS]
- extracellular matrix organization [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- eye development [IDA]
- generation of neurons [TAS]
- glial cell migration [IDA]
- hair follicle development [IDA, ISS]
- hair follicle morphogenesis [ISS]
- heart development [IDA]
- heart morphogenesis [IDA]
- hemopoiesis [ISS]
- negative regulation of alkaline phosphatase activity [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of immune response [TAS]
- negative regulation of macrophage cytokine production [IDA]
- neuron development [ISS]
- neutrophil chemotaxis [ISS, TAS]
- odontogenesis [NAS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cardioblast differentiation [IDA]
- positive regulation of catagen [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell cycle [ISS]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of heart contraction [IDA]
- positive regulation of immune response [ISS]
- positive regulation of integrin biosynthetic process [IDA]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of ossification [IEP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of stress-activated MAPK cascade [IDA]
- protein phosphorylation [IDA]
- regulation of transforming growth factor beta2 production [IMP]
- response to drug [IDA]
- response to hypoxia [IMP]
- response to progesterone [IDA]
- response to wounding [IEP]
- salivary gland morphogenesis [IEP]
- signal transduction by phosphorylation [IDA]
- somatic stem cell division [ISS]
- transforming growth factor beta receptor signaling pathway [IDA]
- uterine wall breakdown [TAS]
- wound healing [ISS]
Gene Ontology Molecular Function- beta-amyloid binding [IDA]
- cytokine activity [TAS]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- receptor binding [IMP]
- receptor signaling protein serine/threonine kinase activity [IDA]
- transforming growth factor beta receptor binding [IDA]
- type II transforming growth factor beta receptor binding [IDA, IPI]
- beta-amyloid binding [IDA]
- cytokine activity [TAS]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- receptor binding [IMP]
- receptor signaling protein serine/threonine kinase activity [IDA]
- transforming growth factor beta receptor binding [IDA]
- type II transforming growth factor beta receptor binding [IDA, IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
BMP2
BDA2, BMP2A
bone morphogenetic protein 2
GO Process (79)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IEP, IMP, TAS]
- BMP signaling pathway involved in heart induction [IDA]
- Notch signaling pathway [ISS]
- SMAD protein signal transduction [IDA]
- activation of MAPK activity [IDA]
- atrioventricular valve morphogenesis [ISS]
- bone mineralization [ISS]
- bone mineralization involved in bone maturation [IDA]
- branching involved in ureteric bud morphogenesis [ISS]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell differentiation [IMP]
- cardiac muscle tissue morphogenesis [ISS]
- cardiocyte differentiation [IDA, IMP]
- cell fate commitment [ISS]
- cell-cell signaling [TAS]
- cellular response to BMP stimulus [IDA]
- chondrocyte differentiation [IDA]
- corticotropin hormone secreting cell differentiation [ISS]
- embryo development [ISS]
- embryonic heart tube anterior/posterior pattern specification [ISS]
- endocardial cushion morphogenesis [ISS]
- epithelial to mesenchymal transition [IDA]
- extracellular matrix organization [TAS]
- heart development [ISS]
- in utero embryonic development [ISS]
- inflammatory response [ISS]
- inner ear development [ISS]
- mesenchymal cell differentiation [IDA]
- mesenchymal cell proliferation involved in ureteric bud development [ISS]
- mesenchyme development [IMP]
- negative regulation of Wnt signaling pathway involved in heart development [IDA]
- negative regulation of aldosterone biosynthetic process [IDA]
- negative regulation of calcium-independent cell-cell adhesion [IDA]
- negative regulation of canonical Wnt signaling pathway [IEP]
- negative regulation of cardiac muscle cell differentiation [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cortisol biosynthetic process [IDA]
- negative regulation of insulin-like growth factor receptor signaling pathway [IDA]
- negative regulation of steroid biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- odontogenesis of dentin-containing tooth [ISS]
- organ morphogenesis [ISS]
- osteoblast differentiation [IDA]
- pathway-restricted SMAD protein phosphorylation [IDA]
- pericardium development [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of Wnt signaling pathway by BMP signaling pathway [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of bone mineralization [IDA]
- positive regulation of cartilage development [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of fat cell differentiation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of neuron differentiation [ISS]
- positive regulation of odontogenesis [ISS]
- positive regulation of ossification [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of osteoblast proliferation [ISS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of phosphatase activity [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to hypoxia [ISS]
- skeletal system development [TAS]
- telencephalon development [IDA]
- telencephalon regionalization [ISS]
- thyroid-stimulating hormone-secreting cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID