BAIT
WNT5A
hWNT5A
wingless-type MMTV integration site family, member 5A
GO Process (54)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- Wnt signaling pathway, calcium modulating pathway [IDA, IMP]
- activation of JUN kinase activity [IDA, IMP]
- activation of MAPK activity [IDA]
- activation of protein kinase B activity [IDA]
- axon guidance [ISS]
- cell fate commitment [IBA]
- cellular protein localization [IDA]
- cellular response to calcium ion [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to retinoic acid [ISS]
- cellular response to transforming growth factor beta stimulus [IEP]
- embryonic skeletal system development [IMP]
- epithelial to mesenchymal transition [IEP]
- face development [IMP]
- genitalia development [IMP]
- hematopoietic stem cell proliferation [IDA]
- keratinocyte differentiation [IEP]
- lens development in camera-type eye [ISS]
- male gonad development [IEP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of mesenchymal cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neuron differentiation [IBA, ISS]
- olfactory bulb interneuron development [ISS]
- optic cup formation involved in camera-type eye development [ISS]
- palate development [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cGMP metabolic process [IDA]
- positive regulation of chemokine biosynthetic process [IMP]
- positive regulation of cytokine secretion involved in immune response [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of inflammatory response [IMP]
- positive regulation of interleukin-1 beta secretion [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of macrophage activation [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of neuron projection development [ISS]
- positive regulation of ossification [IMP]
- positive regulation of protein catabolic process [IGI]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of response to cytokine stimulus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of type I interferon-mediated signaling pathway [IDA]
- response to organic substance [IEP]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FZD5
C2orf31, HFZ5
frizzled class receptor 5
GO Process (10)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- Spemann organizer formation [IDA]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- anterior/posterior axis specification, embryo [IDA]
- canonical Wnt signaling pathway [IDA, IMP]
- cellular response to molecule of bacterial origin [IDA]
- embryonic axis specification [IDA]
- neuron differentiation [ISS]
- non-canonical Wnt signaling pathway [IBA]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID