FLT1
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cell migration [IMP]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- embryonic morphogenesis [ISS]
- monocyte chemotaxis [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phospholipase C activity [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein autophosphorylation [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IMP, TAS]
- vascular endothelial growth factor receptor-1 signaling pathway [IDA]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
Gene Ontology Molecular Function- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
Gene Ontology Cellular Component
PTPN11
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- atrioventricular canal development [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- brain development [IMP]
- cytokine-mediated signaling pathway [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- face morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- genitalia development [IMP]
- heart development [IMP]
- innate immune response [TAS]
- inner ear development [IMP]
- insulin receptor signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
Throughput
- Low Throughput
Additional Notes
- in situ PLA
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FLT1 PTPN11 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | High | - | BioGRID | 3201811 |
Curated By
- BioGRID