HEY2
Gene Ontology Biological Process
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [ISS, TAS]
- arterial endothelial cell differentiation [ISS]
- ascending aorta morphogenesis [ISS]
- atrial septum morphogenesis [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac left ventricle morphogenesis [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac septum morphogenesis [ISS]
- cardiac ventricle morphogenesis [ISS]
- dorsal aorta morphogenesis [ISS]
- labyrinthine layer blood vessel development [ISS]
- mesenchymal cell development [ISS]
- muscular septum morphogenesis [ISS]
- negative regulation of cardiac vascular smooth muscle cell differentiation [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of transcription by transcription factor localization [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [ISS]
- negative regulation of transcription initiation from RNA polymerase II promoter [IDA]
- negative regulation of transcription regulatory region DNA binding [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- outflow tract morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- pulmonary artery morphogenesis [ISS]
- pulmonary valve morphogenesis [ISS]
- regulation of vasculogenesis [ISS]
- smooth muscle cell differentiation [NAS]
- tricuspid valve morphogenesis [ISS]
- umbilical cord morphogenesis [ISS]
- vascular smooth muscle cell development [IEP]
- vasculogenesis [ISS]
- ventricular cardiac muscle cell development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- histone deacetylase binding [IPI]
- microsatellite binding [IDA]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- histone deacetylase binding [IPI]
- microsatellite binding [IDA]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
FBXO45
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.
The Hey protein family, comprising Hey1, Hey2 and HeyL in mammals, conveys Notch signals in many cell types. The helix-loop-helix (HLH) domain as well as the Orange domain, mediate homo- and heterodimerization of these transcription factors. Although distinct interaction partners have been identified so far, their physiological relevance for Hey functions is still largely unclear. Using a tandem affinity purification ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID