PPARA
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- circadian regulation of gene expression [ISS]
- fatty acid transport [TAS]
- gene expression [TAS]
- intracellular receptor signaling pathway [IDA]
- lipid metabolic process [TAS]
- negative regulation of appetite [ISS]
- negative regulation of cholesterol storage [IDA]
- negative regulation of glycolytic process [IC]
- negative regulation of macrophage derived foam cell differentiation [IC, IDA]
- negative regulation of receptor biosynthetic process [IDA]
- negative regulation of sequestering of triglyceride [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of fatty acid beta-oxidation [TAS]
- positive regulation of fatty acid oxidation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of circadian rhythm [ISS]
- regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter [IDA]
- small molecule metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- drug binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- lipid binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- steroid hormone receptor activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- drug binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- lipid binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- steroid hormone receptor activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [TAS]
CDC34
Gene Ontology Biological Process
- DNA replication initiation [NAS]
- G1/S transition of mitotic cell cycle [NAS]
- cellular protein modification process [NAS]
- negative regulation of cAMP-mediated signaling [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K48-linked ubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, NAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
PPARα induces cell apoptosis by destructing Bcl2.
PPARα belongs to the peroxisome-proliferator-activated receptors (PPARs) family, which plays a critical role in inhibiting cell proliferation and tumorigenesis, while the molecular mechanism is still unclear. Here we report that PPARα serves as an E3 ubiquitin ligase to govern Bcl2 protein stability. PPARα physically bound to Bcl2 protein. In this process, PPARα/C102 was critical for PPARα binding to BH3 domain ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID