MEFV
Gene Ontology Biological Process
- inflammatory response [IDA]
- innate immune response [TAS]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-12 production [IMP]
- negative regulation of macrophage inflammatory protein 1 alpha production [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of cysteine-type endopeptidase activity [IDA]
Gene Ontology Molecular Function
ATG16L1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
The present paradigms of selective autophagy in mammalian cells cannot fully explain the specificity and selectivity of autophagic degradation. In this paper, we report that a subset of tripartite motif (TRIM) proteins act as specialized receptors for highly specific autophagy (precision autophagy) of key components of the inflammasome and type I interferon response systems. TRIM20 targets the inflammasome components, including ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID