LRP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- apical part of cell [IDA]
- apical plasma membrane [IDA, ISO]
- brush border [IDA, ISO]
- brush border membrane [IDA, ISO]
- coated pit [IDA]
- cytoplasm [ISO]
- endocytic vesicle [IDA]
- endoplasmic reticulum [IDA]
- endosome [IDA, ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- lysosomal membrane [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- protein complex [ISO]
- receptor complex [ISO]
DYNC1I2
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
Receptors internalized by endocytosis can return to the plasma membrane (PM) directly from early endosomes (EE; fast recycling) or they can traffic from EE to the endocytic recycling compartment (ERC) and recycle from there (slow recycling). How receptors are sorted for trafficking along these two pathways remains unclear. Here we show that autosomal recessive hypercholesterolemia (ARH) is required for trafficking ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID