BAIT

PDIA2

PDA2, PDI, PDIP, PDIR, LA16c-314G4.2
protein disulfide isomerase family A, member 2
Alzheimer's Disease Project
Homo sapiens
PREY

MTTP

ABL, MTP
microsomal triglyceride transfer protein
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Novel missense MTTP gene mutations causing abetalipoproteinemia.

Miller SA, Burnett JR, Leonis MA, McKnight CJ, van Bockxmeer FM, Hooper AJ

The microsomal triglyceride transfer protein (MTTP) plays a critical role in the formation of hepatic very low density lipoprotein. Abetalipoproteinemia (ABL) is a rare, naturally occurring extreme form of MTTP inhibition, which is characterized by the virtual absence of apolipoprotein (apo) B-containing lipoproteins in blood. The goal of this study was to examine the effect that four novel MTTP missense ... [more]

Biochim. Biophys. Acta Oct. 01, 2014; 1842(10);1548-54 [Pubmed: 25108285]

Throughput

  • Low Throughput

Curated By

  • BioGRID