BAIT
LMO2
Rbtn-2, Rbtn2, Rhom-2, Ttg2, RP23-261L3.1
LIM domain only 2
GO Process (5)
GO Function (11)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- cofactor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- DNA binding [IDA]
- E-box binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- cofactor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
MPO
mKIAA4033, RP23-449P23.5
myeloperoxidase
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- defense response to Gram-positive bacterium [IMP]
- defense response to fungus [IMP]
- hydrogen peroxide catabolic process [IDA, IMP, ISO]
- hypochlorous acid biosynthetic process [IMP]
- low-density lipoprotein particle remodeling [ISO]
- negative regulation of growth of symbiont in host [IMP]
- oxidation-reduction process [IMP, ISO]
- removal of superoxide radicals [IMP]
- respiratory burst involved in defense response [IMP]
- response to yeast [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The LMO2 oncogene regulates DNA replication in hematopoietic cells.
Oncogenic transcription factors are commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hematopoietic progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphoblastic leukemia (T-ALL). Whether or not these oncoproteins interfere with other DNA-dependent processes is largely unexplored. Here, we show that LMO2 is recruited to DNA replication origins by ... [more]
Proc. Natl. Acad. Sci. U.S.A. Feb. 02, 2016; 113(5);1393-8 [Pubmed: 26764384]
Throughput
- High Throughput
Curated By
- BioGRID