LMO2
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- cofactor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- DNA binding [IDA]
- E-box binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- cofactor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
Gene Ontology Cellular Component
LRCH4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The LMO2 oncogene regulates DNA replication in hematopoietic cells.
Oncogenic transcription factors are commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hematopoietic progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphoblastic leukemia (T-ALL). Whether or not these oncoproteins interfere with other DNA-dependent processes is largely unexplored. Here, we show that LMO2 is recruited to DNA replication origins by ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LMO2 LRCH4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID