RC3H1
Gene Ontology Biological Process
- B cell homeostasis [IGI]
- T cell homeostasis [IGI]
- T cell proliferation [IGI]
- T follicular helper cell differentiation [IGI]
- cytoplasmic mRNA processing body assembly [IMP]
- lymph node development [IGI]
- negative regulation of B cell proliferation [IMP]
- negative regulation of T-helper cell differentiation [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of germinal center formation [IMP]
- nuclear-transcribed mRNA catabolic process [IMP]
- positive regulation of NIK/NF-kappaB signaling [IDA]
- posttranscriptional regulation of gene expression [IDA, IMP]
- regulation of T cell receptor signaling pathway [IMP]
- regulation of gene expression [IDA]
- regulation of germinal center formation [IMP]
- regulation of mRNA stability [IMP]
- spleen development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKAA1
Gene Ontology Biological Process
- cellular response to glucose starvation [IDA]
- cellular response to nutrient levels [IDA]
- cellular response to prostaglandin E stimulus [IGI]
- cold acclimation [ISO]
- fatty acid homeostasis [ISO]
- fatty acid oxidation [IMP]
- glucose homeostasis [IMP]
- glucose metabolic process [IMP]
- histone-serine phosphorylation [IDA]
- lipid biosynthetic process [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of glucose import in response to insulin stimulus [ISO]
- negative regulation of lipid catabolic process [IDA]
- positive regulation of autophagy [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of glycolytic process [ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IMP, ISO]
- regulation of circadian rhythm [IMP]
- regulation of energy homeostasis [ISO]
- regulation of vesicle-mediated transport [ISO]
- response to UV [IMP]
- response to activity [ISO]
- response to caffeine [ISO]
- response to camptothecin [IMP]
- response to gamma radiation [IMP]
- response to hydrogen peroxide [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.
T follicular helper cells (Tfh) are critical for the longevity and quality of antibody-mediated protection against infection. Yet few signaling pathways have been identified to be unique solely to Tfh development. ROQUIN is a post-transcriptional repressor of T cells, acting through its ROQ domain to destabilize mRNA targets important for Th1, Th17, and Tfh biology. Here, we report that ROQUIN ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PRKAA1 RC3H1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1505769 | |
PRKAA1 RC3H1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 1505768 |
Curated By
- BioGRID