GRIK2
Gene Ontology Biological Process
- behavioral fear response [ISO]
- cellular calcium ion homeostasis [ISO]
- intracellular protein transport [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, glutamatergic [IDA, ISO]
- neuron apoptotic process [IMP]
- neuronal action potential [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [IDA]
- regulation of JNK cascade [IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of short-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- signal transduction [IDA]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- axon [IDA]
- cell [ISO]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intracellular [ISO]
- ionotropic glutamate receptor complex [IDA]
- kainate selective glutamate receptor complex [IBA, ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- perikaryon [IDA]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- terminal bouton [IDA]
PARK2
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- aggresome assembly [IMP]
- cellular protein catabolic process [IMP]
- cellular response to dopamine [TAS]
- cellular response to manganese ion [TAS]
- cellular response to toxic substance [IMP]
- cellular response to unfolded protein [TAS]
- central nervous system development [TAS]
- dopamine metabolic process [TAS]
- mitochondrial fission [ISS]
- mitochondrion degradation [IMP, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell death [IDA]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of glucokinase activity [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IGI]
- negative regulation of oxidative stress-induced cell death [NAS, TAS]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of reactive oxygen species metabolic process [IGI]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- neuron cellular homeostasis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [IMP]
- positive regulation of proteasomal protein catabolic process [IGI]
- positive regulation of protein linear polyubiquitination [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K27-linked ubiquitination [TAS]
- protein K29-linked ubiquitination [TAS]
- protein K48-linked ubiquitination [IDA]
- protein K6-linked ubiquitination [TAS]
- protein K63-linked ubiquitination [IDA, TAS]
- protein autoubiquitination [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IC, IDA, NAS, TAS]
- regulation of autophagy [IDA]
- regulation of cellular response to oxidative stress [ISS]
- regulation of dopamine secretion [TAS]
- regulation of glucose metabolic process [TAS]
- regulation of lipid transport [TAS]
- regulation of mitochondrion degradation [TAS]
- regulation of mitochondrion organization [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of synaptic vesicle transport [NAS]
- response to endoplasmic reticulum stress [IMP]
- response to oxidative stress [ISS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Although loss-of-function mutations in the PARK2 gene, the gene that encodes the protein parkin, cause autosomal recessive juvenile parkinsonism, the responsible molecular mechanisms remain unclear. Evidence suggests that a loss of parkin dysregulates excitatory synapses. Here we show that parkin interacts with the kainate receptor (KAR) GluK2 subunit and regulates KAR function. Loss of parkin function in primary cultured neurons ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIK2 PARK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1505771 | |
| PARK2 GRIK2 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1505775 |
Curated By
- BioGRID