BIN1
Gene Ontology Biological Process
- lipid tube assembly [ISO]
- muscle cell differentiation [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of endocytosis [ISO]
- regulation of cell cycle arrest [ISO]
- regulation of neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
E2F1
Gene Ontology Biological Process
- DNA damage checkpoint [ISO]
- anoikis [IDA]
- cellular response to nerve growth factor stimulus [ISO]
- forebrain development [IMP]
- intrinsic apoptotic signaling pathway by p53 class mediator [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- lens fiber cell apoptotic process [IDA]
- mRNA stabilization [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of cell cycle [IDA]
- regulation of transcription, DNA-templated [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation.
The transcription factor adenovirus E2 promoter-binding factor (E2F)-1 normally enhances cell-cycle progression, but it also induces apoptosis under certain conditions, including DNA damage and serum deprivation. Although DNA damage facilitates the phosphorylation and stabilization of E2F1 to trigger apoptosis, how serum starvation renders cells vulnerable to E2F1-induced apoptosis remains unclear. Because poly(ADP-ribose) polymerase 1 (PARP1), a nuclear enzyme essential for ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 5
Curated By
- BioGRID