BAIT
TCF4
E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19
transcription factor 4
GO Process (6)
GO Function (11)
GO Component (2)
Gene Ontology Biological Process
- DNA-templated transcription, initiation [ISS]
- positive regulation of neuron differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- protein-DNA complex assembly [ISS]
- transcription initiation from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- TFIIB-class binding transcription factor activity [ISS]
- TFIIB-class transcription factor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS, NAS]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- TFIIB-class binding transcription factor activity [ISS]
- TFIIB-class transcription factor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS, NAS]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
HAND1
Hxt, Thing1, bHLHa27, eHand
heart and neural crest derivatives expressed 1
GO Process (16)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [ISS]
- blastocyst development [IEP]
- cardiac left ventricle formation [IMP]
- cardiac right ventricle formation [IMP]
- cardiac septum morphogenesis [IMP]
- embryonic heart tube development [ISS]
- heart development [ISS]
- heart looping [ISS]
- negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IEP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [NAS]
- transcription coactivator activity [IC, IDA]
- transcription corepressor activity [IC]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [NAS]
- transcription coactivator activity [IC, IDA]
- transcription corepressor activity [IC]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein-protein interactions remains limited. Here, we performed proteomics analyses of soluble and chromatin-associated complexes of 56 TFs, including the targets of many signalling pathways involved in development and cancer, and 37 members of the Forkhead box (FOX) TF family. Using ... [more]
Mol. Syst. Biol. Jan. 01, 2015; 11(1);775 [Pubmed: 25609649]
Throughput
- High Throughput
Additional Notes
- High-confidence interactions
Curated By
- BioGRID