BAIT
RC3H1
RNF198, ROQUIN, RP5-1198E17.5
ring finger and CCCH-type domains 1
GO Process (11)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cytoplasmic mRNA processing body assembly [ISS]
- negative regulation of B cell proliferation [ISS]
- negative regulation of T-helper cell differentiation [ISS]
- negative regulation of activated T cell proliferation [ISS]
- negative regulation of germinal center formation [ISS]
- nuclear-transcribed mRNA catabolic process [ISS]
- posttranscriptional regulation of gene expression [ISS]
- protein ubiquitination [TAS]
- regulation of T cell receptor signaling pathway [ISS]
- regulation of germinal center formation [ISS]
- regulation of mRNA stability [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBE2N
HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13
ubiquitin-conjugating enzyme E2N
GO Process (30)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- DNA double-strand break processing [IMP]
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IMP, TAS]
- cellular protein modification process [TAS]
- cytokine-mediated signaling pathway [TAS]
- double-strand break repair via homologous recombination [IMP]
- histone ubiquitination [IMP]
- innate immune response [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of DNA repair [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of histone modification [IMP]
- positive regulation of ubiquitin-protein transferase activity [IMP]
- postreplication repair [IMP]
- protein K63-linked ubiquitination [IDA]
- protein ubiquitination [IMP, TAS]
- proteolysis [TAS]
- regulation of DNA repair [TAS]
- regulation of histone ubiquitination [IMP]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-type E3 ubiquitin ligase domain. They repress constitutive decay elements containing mRNAs and play a critical role in RNA homeostasis and immunological self-tolerance. Here we present the crystal structures of the RNA-binding region of Roquin paralog RC3H2 in both apo- and RNA-bound forms. The RNA-binding region has ... [more]
Sci Rep Oct. 23, 2015; 5(0);15660 [Pubmed: 26489670]
Throughput
- Low Throughput
Additional Notes
- Formation of polyubiquitin chains in vitro
- The reaction contained E1, different E2s and Roquin (RC3H2).
Curated By
- BioGRID