BAIT
SHARPIN
SIPL1, PSEC0216
SHANK-associated RH domain interactor
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGB2
CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
GO Process (20)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [NAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell-cell signaling [NAS]
- cell-matrix adhesion [IMP]
- endodermal cell differentiation [IEP]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- inflammatory response [NAS]
- innate immune response [TAS]
- integrin-mediated signaling pathway [NAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- neutrophil chemotaxis [IDA]
- receptor clustering [IMP]
- regulation of cell shape [NAS]
- regulation of immune response [TAS]
- regulation of peptidyl-tyrosine phosphorylation [IDA]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling.
SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of the linear ubiquitin chain assembly complex (LUBAC). However, it is currently unclear how regulation of these seemingly different roles is coordinated. Here, we show that SHARPIN binds integrin and LUBAC in a mutually exclusive manner. ... [more]
PLoS ONE Nov. 26, 2015; 10(11);e0143423 [Pubmed: 26600301]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITGB2 SHARPIN | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | - |
Curated By
- BioGRID