RAC1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IGI]
- GTP catabolic process [IDA, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI]
- actin cytoskeleton organization [ISO]
- actin filament organization [ISO]
- actin filament polymerization [IDA]
- anatomical structure arrangement [IMP]
- auditory receptor cell morphogenesis [IMP]
- axon guidance [IMP]
- bone resorption [ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell motility [ISO]
- cell proliferation [ISO]
- cell-cell junction organization [IMP]
- cellular component movement [ISO]
- cerebral cortex radially oriented cell migration [IMP]
- chemotaxis [ISO]
- cochlea morphogenesis [IMP]
- cytoskeleton organization [IDA]
- dendrite development [IDA]
- dendrite morphogenesis [IGI]
- dopaminergic neuron differentiation [IGI]
- embryonic olfactory bulb interneuron precursor migration [IMP]
- endocytosis [IDA]
- engulfment of apoptotic cell [IDA]
- epithelial cell morphogenesis [IMP]
- hyperosmotic response [IDA]
- lamellipodium assembly [IDA, ISO, TAS]
- localization within membrane [ISO]
- mast cell chemotaxis [ISO]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [IMP, ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [IDA]
- regulation of cell migration [IMP, ISO]
- regulation of respiratory burst [ISO]
- ruffle assembly [IMP]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [ISO]
- small GTPase mediated signal transduction [IDA]
- substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISO]
- actin filament [ISO]
- cell projection [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [IDA]
- focal adhesion [ISO]
- lamellipodium [IDA, ISO]
- membrane [IDA, ISO]
- phagocytic cup [IDA]
- ruffle membrane [IDA]
- trans-Golgi network [ISO]
RCC2
Gene Ontology Biological Process
- chromosome passenger complex localization to kinetochore [IMP]
- focal adhesion assembly [IDA]
- integrin-mediated signaling pathway [IDA]
- mitotic cell cycle [TAS]
- negative regulation of GTPase activity [ISS]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of attachment of spindle microtubules to kinetochore [IMP]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure.
Sustained forward migration through a fibrillar extracellular matrix requires localization of protrusive signals. Contact with fibronectin at the tip of a cell protrusion activates Rac1, and for linear migration it is necessary to dampen Rac1 activity in off-axial positions and redistribute Rac1 from non-protrusive membrane to the leading edge. Here, we identify interactions between coronin-1C (Coro1C), RCC2 and Rac1 that ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RCC2 RAC1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 1507210 |
Curated By
- BioGRID