SPOP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PUC
Gene Ontology Biological Process
- JNK cascade [IMP, NAS, TAS]
- actin cytoskeleton organization [IMP]
- actin filament organization [IMP]
- border follicle cell migration [IGI]
- cellular response to oxidative stress [IDA]
- chitin-based embryonic cuticle biosynthetic process [IMP]
- compound eye development [IMP]
- determination of adult lifespan [IMP]
- determination of digestive tract left/right asymmetry [IMP]
- dorsal appendage formation [IMP]
- dorsal closure [IMP, NAS, TAS]
- embryonic anterior midgut (ectodermal) morphogenesis [IMP]
- epidermis development [IMP]
- establishment of planar polarity [NAS]
- imaginal disc eversion [IMP]
- imaginal disc fusion [IMP]
- imaginal disc fusion, thorax closure [IGI]
- inactivation of MAPK activity [IBA]
- micropyle formation [IMP]
- negative regulation of JNK cascade [NAS, TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of stress-activated protein kinase signaling cascade [IMP]
- ommatidial rotation [NAS]
- ovarian follicle cell development [IMP, TAS]
- peripheral nervous system development [TAS]
- positive regulation of immune response [IMP]
- protein dephosphorylation [IBA, IDA, ISS, NAS]
- protein secretion [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell shape [IMP]
- response to oxidative stress [IMP]
- suture of dorsal opening [NAS]
- wound healing [IDA, IEP, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.
Primary sequence motifs, with millimolar affinities for binding partners, are abundant in disordered protein regions. In multivalent interactions, such weak linear motifs can cooperate to recruit binding partners via avidity effects. If linear motifs recruit modifying enzymes, optimal placement of weak motifs may regulate access to modification sites. Weak motifs may thus exert physiological relevance stronger than that suggested by ... [more]
Throughput
- Low Throughput
Additional Notes
- NMR
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SPOP PUC | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | 1507984 |
Curated By
- BioGRID