HLA-DRA
Gene Ontology Biological Process
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [IDA]
- cognition [IMP]
- cytokine-mediated signaling pathway [TAS]
- immune response [NAS]
- interferon-gamma-mediated signaling pathway [TAS]
- peptide antigen assembly with MHC class II protein complex [IDA]
- polysaccharide assembly with MHC class II protein complex [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- MHC class II protein complex [IDA]
- cell surface [IDA]
- clathrin-coated endocytic vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of plasma membrane [NAS]
- late endosome membrane [IDA]
- lysosomal membrane [IDA, TAS]
- lysosome [IDA]
- plasma membrane [IDA, TAS]
- trans-Golgi network membrane [TAS]
- transport vesicle membrane [TAS]
TOLLIP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tollip-induced down-regulation of MARCH1.
In addition to their classical antigen presenting functions, MHC class II molecules potentiate the TLR-triggered production of pro-inflammatory cytokines. Here, we have addressed the effect of Tollip and MARCH1 on the regulation of MHC II trafficking and TLR signaling. Our results show that MARCH1-deficient mice splenocytes are impaired in their capacity to produce pro-inflammatory cytokines in response to poly(I:C) and ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 6
Curated By
- BioGRID