BAIT
SOCS2
8030460M17, AI527257, AW108012, CIS2, Cish2, D130043N08Rik, JAB, SOCS-2, SSI-2, hg
suppressor of cytokine signaling 2
GO Process (13)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [IBA]
- growth hormone receptor signaling pathway [ISO]
- intracellular signal transduction [IMP]
- lactation [IGI, IMP]
- mammary gland alveolus development [IGI, IMP]
- negative regulation of JAK-STAT cascade [IGI]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of multicellular organism growth [IGI, IMP]
- negative regulation of protein kinase activity [IBA]
- positive regulation of neuron differentiation [IDA]
- regulation of multicellular organism growth [IMP]
- response to estradiol [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NTRK2
RATTRKB1, TRKB1, Tkrb, trk-B, trkB
neurotrophic tyrosine kinase, receptor, type 2
GO Process (44)
GO Function (8)
GO Component (24)
Gene Ontology Biological Process
- aging [IEP]
- brain-derived neurotrophic factor receptor signaling pathway [IDA, IMP, ISO]
- calcium-mediated signaling using intracellular calcium source [ISO]
- cellular response to brain-derived neurotrophic factor stimulus [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to tumor necrosis factor [IEP]
- central nervous system neuron development [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- feeding behavior [ISO]
- glutamate secretion [ISO]
- inflammatory response [IEP]
- learning [ISO, ISS]
- long-term memory [IDA]
- long-term synaptic potentiation [ISO]
- mechanoreceptor differentiation [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of neuron apoptotic process [IMP]
- neuromuscular junction development [ISO]
- neuron differentiation [ISO, ISS]
- neuron migration [ISO, ISS]
- neurotrophin signaling pathway [IDA, IMP, ISO]
- oligodendrocyte differentiation [ISO]
- peptidyl-tyrosine phosphorylation [IMP, ISO]
- peripheral nervous system neuron development [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of axonogenesis [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [ISO, ISS]
- positive regulation of glucocorticoid receptor signaling pathway [IGI]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein autophosphorylation [IDA, IMP]
- regulation of MAPK cascade [IDA]
- regulation of Rac GTPase activity [ISO, ISS]
- regulation of dendrite development [IMP]
- regulation of metabolic process [ISO]
- regulation of neurotransmitter secretion [IDA]
- regulation of protein kinase B signaling [ISO]
- response to auditory stimulus [IEP]
- response to light stimulus [IEP]
- retinal rod cell development [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- brain-derived neurotrophic factor binding [IDA, IMP, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [IPI]
- neurotrophin binding [IDA, ISO, ISS]
- neurotrophin receptor activity [IDA, IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IMP]
- brain-derived neurotrophic factor binding [IDA, IMP, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [IPI]
- neurotrophin binding [IDA, ISO, ISS]
- neurotrophin receptor activity [IDA, IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- axon [IDA]
- axon terminus [IDA]
- cell [ISO]
- cell surface [IDA]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendritic spine [IDA]
- endosome [ISO]
- excitatory synapse [IDA]
- growth cone [IDA]
- integral component of plasma membrane [IDA, ISO]
- intracellular [ISO]
- neuronal cell body [IDA]
- neuronal postsynaptic density [ISO]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- postsynaptic density [IDA]
- postsynaptic membrane [ISO]
- presynaptic active zone [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- terminal bouton [ISO]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology.
Suppressor of cytokine signaling-2 (SOCS2) is a regulator of intracellular responses to growth factors and cytokines. Cultured dorsal root ganglia neurons from neonatal mice with increased or decreased SOCS2 expression were examined for altered responsiveness to nerve growth factor (NGF). In the presence of NGF, SOCS2 over-expression increased neurite length and complexity, whereas loss of SOCS2 reduced neurite outgrowth. Neither ... [more]
J. Neurochem. May. 01, 2014; 129(4);614-27 [Pubmed: 24484474]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Curated By
- BioGRID