SOCS2
Gene Ontology Biological Process
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [IBA]
- growth hormone receptor signaling pathway [ISO]
- intracellular signal transduction [IMP]
- lactation [IGI, IMP]
- mammary gland alveolus development [IGI, IMP]
- negative regulation of JAK-STAT cascade [IGI]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of multicellular organism growth [IGI, IMP]
- negative regulation of protein kinase activity [IBA]
- positive regulation of neuron differentiation [IDA]
- regulation of multicellular organism growth [IMP]
- response to estradiol [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NTRK3
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- activation of Ras GTPase activity [ISO]
- activation of protein kinase B activity [ISO]
- cellular response to retinoic acid [IEP]
- cochlea development [IEP]
- lens fiber cell differentiation [ISO]
- mechanoreceptor differentiation [ISO]
- modulation by virus of host transcription [IEP]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of cell death [IMP]
- negative regulation of protein phosphorylation [ISO]
- neuron fate specification [IMP]
- neuron migration [IMP]
- neurotrophin signaling pathway [IMP, ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of axon extension involved in regeneration [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of positive chemotaxis [ISO]
- protein autophosphorylation [IMP]
- response to axon injury [IEP]
- response to corticosterone [IEP]
- response to ethanol [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology.
Suppressor of cytokine signaling-2 (SOCS2) is a regulator of intracellular responses to growth factors and cytokines. Cultured dorsal root ganglia neurons from neonatal mice with increased or decreased SOCS2 expression were examined for altered responsiveness to nerve growth factor (NGF). In the presence of NGF, SOCS2 over-expression increased neurite length and complexity, whereas loss of SOCS2 reduced neurite outgrowth. Neither ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Curated By
- BioGRID