AURKA
Gene Ontology Biological Process
- anterior/posterior axis specification [IMP]
- centrosome localization [IMP]
- centrosome organization [IGI]
- histone-serine phosphorylation [IMP]
- meiotic nuclear division [IMP]
- meiotic spindle organization [IMP]
- microtubule cytoskeleton organization [IGI]
- mitotic cell cycle [IMP]
- mitotic centrosome separation [IGI, IMP]
- mitotic nuclear division [IMP]
- mitotic spindle organization [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein binding [ISO]
- negative regulation of spindle checkpoint [IMP]
- neuron projection extension [IGI]
- positive regulation of oocyte maturation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- protein localization to centrosome [IMP]
- protein phosphorylation [IBA, IGI, ISO]
- regulation of cytokinesis [IBA]
- regulation of protein stability [ISO]
- spindle assembly involved in female meiosis I [IMP]
- spindle stabilization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon hillock [IDA]
- centrosome [IDA, ISO]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- germinal vesicle [IDA]
- meiotic spindle [IDA]
- microtubule cytoskeleton [ISO]
- microtubule organizing center [IGI]
- mitotic spindle [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- pronucleus [IDA]
- spindle [ISO]
- spindle microtubule [IBA, ISO]
- spindle midzone [IBA]
- spindle pole centrosome [IBA, ISO]
NEDD9
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.
The prometastatic protein NEDD9 (neural precursor cell expressed, developmentally downregulated 9) is highly expressed in many cancers and is required for mesenchymal individual cell migration and progression to the invasive stage. Nevertheless, the molecular mechanisms of NEDD9-driven migration and the downstream targets effecting metastasis are not well defined. In the current study, knockdown of NEDD9 in highly metastatic tumor cells ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NEDD9 AURKA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID