BAIT
FBXO31
FBX14, FBXO14, Fbx31, MRT45, PP2386
F-box protein 31
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GHR
GHBP
growth hormone receptor
GO Process (27)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [ISS]
- JAK-STAT cascade [ISS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- activation of JAK2 kinase activity [ISS]
- activation of MAPK activity [ISS]
- allantoin metabolic process [ISS]
- cellular response to hormone stimulus [IMP]
- citrate metabolic process [ISS]
- creatine metabolic process [ISS]
- creatinine metabolic process [ISS]
- fatty acid metabolic process [ISS]
- growth hormone receptor signaling pathway [IMP]
- insulin-like growth factor receptor signaling pathway [IMP]
- isoleucine metabolic process [ISS]
- multicellular organismal metabolic process [IMP]
- oxaloacetate metabolic process [ISS]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- receptor internalization [IDA]
- regulation of multicellular organism growth [ISS]
- response to cycloheximide [IDA]
- response to estradiol [IDA]
- succinate metabolic process [ISS]
- taurine metabolic process [ISS]
- valine metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
The multisubunit cullin RING E3 ubiquitin ligases (CRLs) target post-translationally modified substrates for ubiquitination and proteasomal degradation. The suppressors of cytokine signaling (SOCS) proteins play important roles in inflammatory processes, diabetes, and cancer and therefore represent attractive targets for therapeutic intervention. The SOCS proteins, among their other functions, serve as substrate receptors of CRL5 complexes. A member of the CRL ... [more]
J. Biol. Chem. Feb. 13, 2015; 290(7);4178-91 [Pubmed: 25505247]
Throughput
- Low Throughput
Additional Notes
- Figure 1
- GHR peptide with Tyr(P)595
Curated By
- BioGRID