DACT1
Gene Ontology Biological Process
- embryonic hindgut morphogenesis [ISS]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of JNK cascade [IDA]
- negative regulation of Wnt signaling pathway [IDA, IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of catenin import into nucleus [IMP]
- positive regulation of protein catabolic process [IDA]
- regulation of Wnt signaling pathway, planar cell polarity pathway [ISS]
- regulation of catenin import into nucleus [IMP]
- regulation of nodal signaling pathway [IDA]
- regulation of protein stability [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ZBTB17
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.
Wnt signalling regulates embryonic development and tissue homoeostasis by modulating cell proliferation, differentiation and migration. Dapper1 (Dpr1) has been shown to be an important key negative regulator of Wnt signalling by promoting Dishevelled (Dvl) degradation. In the present study, we found that Myc-interacting zinc-finger protein 1 (MIZ1) interacts with Dpr1 and this interaction attenuates the ability of Dpr1 to induce ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 1
- Figure 3
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ZBTB17 DACT1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1508372 |
Curated By
- BioGRID