BAIT
SKI
SGS, SKV
SKI proto-oncogene
GO Process (37)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- SMAD protein signal transduction [IDA]
- anterior/posterior axis specification [ISS]
- bone morphogenesis [ISS]
- camera-type eye development [ISS]
- camera-type eye morphogenesis [ISS]
- cell motility [NAS]
- cell proliferation [NAS]
- embryonic limb morphogenesis [ISS]
- face morphogenesis [ISS]
- gene expression [TAS]
- lens morphogenesis in camera-type eye [ISS]
- myelination in peripheral nervous system [ISS]
- myotube differentiation [IDA]
- negative regulation of BMP signaling pathway [IDA, IMP]
- negative regulation of Schwann cell proliferation [IGI]
- negative regulation of activin receptor signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of osteoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, IGI, IMP]
- neural tube closure [ISS]
- nose morphogenesis [ISS]
- olfactory bulb development [ISS]
- palate development [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of Wnt signaling pathway [NAS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- protein homotrimerization [IDA]
- regulation of apoptotic process [IBA]
- retina development in camera-type eye [ISS]
- skeletal muscle fiber development [ISS]
- somatic stem cell maintenance [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [NAS, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACTB
BRWS1, PS1TP5BP1
actin, beta
GO Process (17)
GO Function (8)
GO Component (15)
Gene Ontology Biological Process
- 'de novo' posttranslational protein folding [TAS]
- ATP-dependent chromatin remodeling [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adherens junction organization [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component movement [TAS]
- cellular protein metabolic process [TAS]
- chromatin organization [TAS]
- innate immune response [TAS]
- membrane organization [TAS]
- platelet aggregation [IMP]
- protein folding [TAS]
- retina homeostasis [IEP]
- substantia nigra development [IEP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- Tat protein binding [IPI]
- kinesin binding [IPI]
- nitric-oxide synthase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- structural constituent of cytoskeleton [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- Tat protein binding [IPI]
- kinesin binding [IPI]
- nitric-oxide synthase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- structural constituent of cytoskeleton [TAS]
Gene Ontology Cellular Component
- MLL5-L complex [IDA]
- NuA4 histone acetyltransferase complex [IDA]
- blood microparticle [IDA]
- cytoplasm [TAS]
- cytoplasmic ribonucleoprotein granule [IDA]
- cytoskeleton [TAS]
- cytosol [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- nuclear chromatin [IDA]
- nucleoplasm [TAS]
- protein complex [IDA]
- ribonucleoprotein complex [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.
Ski, the transforming protein of the avian Sloan-Kettering retrovirus, inhibits transforming growth factor-β (TGF-β)/Smad signaling and displays both pro-oncogenic and anti-oncogenic activities in human cancer. Inhibition of TGF-β signaling is likely responsible for the pro-oncogenic activity of Ski. We investigated the mechanism(s) underlying the tumor suppressor activity of Ski and found that Ski suppressed the activity of the Hippo signaling ... [more]
Sci Signal Feb. 10, 2015; 8(363);ra14 [Pubmed: 25670202]
Throughput
- High Throughput
Additional Notes
- Table S1
Curated By
- BioGRID