BAIT

SKI

SGS, SKV
SKI proto-oncogene
GO Process (37)
GO Function (9)
GO Component (9)

Gene Ontology Biological Process

Homo sapiens
PREY

PFKP

ATP-PFK, PFK-C, PFK-P, PFKF, RP11-298E9.2
phosphofructokinase, platelet
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.

Rashidian J, Le Scolan E, Ji X, Zhu Q, Mulvihill MM, Nomura D, Luo K

Ski, the transforming protein of the avian Sloan-Kettering retrovirus, inhibits transforming growth factor-β (TGF-β)/Smad signaling and displays both pro-oncogenic and anti-oncogenic activities in human cancer. Inhibition of TGF-β signaling is likely responsible for the pro-oncogenic activity of Ski. We investigated the mechanism(s) underlying the tumor suppressor activity of Ski and found that Ski suppressed the activity of the Hippo signaling ... [more]

Sci Signal Feb. 10, 2015; 8(363);ra14 [Pubmed: 25670202]

Throughput

  • High Throughput

Additional Notes

  • Table S1

Curated By

  • BioGRID