BAIT
CRY1
PHLL1
cryptochrome circadian clock 1
GO Process (15)
GO Function (11)
GO Component (1)
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [ISS]
- blue light signaling pathway [NAS]
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- gluconeogenesis [ISS]
- glucose homeostasis [ISS]
- negative regulation of G-protein coupled receptor protein signaling pathway [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of protein ubiquitination [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISS]
- regulation of DNA damage checkpoint [ISS]
- regulation of circadian rhythm [ISS]
- response to glucagon [ISS]
Gene Ontology Molecular Function- DNA (6-4) photolyase activity [IDA]
- DNA binding [TAS]
- blue light photoreceptor activity [NAS]
- core promoter binding [ISS]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- double-stranded DNA binding [IDA]
- nuclear hormone receptor binding [IPI]
- phosphatase binding [IPI]
- protein binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin binding [ISS]
- DNA (6-4) photolyase activity [IDA]
- DNA binding [TAS]
- blue light photoreceptor activity [NAS]
- core promoter binding [ISS]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- double-stranded DNA binding [IDA]
- nuclear hormone receptor binding [IPI]
- phosphatase binding [IPI]
- protein binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin binding [ISS]
Homo sapiens
PREY
C1QBP
GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32
complement component 1, q subcomponent binding protein
GO Process (21)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- immune response [TAS]
- mature ribosome assembly [IMP]
- negative regulation of MDA-5 signaling pathway [IDA]
- negative regulation of RIG-I signaling pathway [IDA]
- negative regulation of defense response to virus [IMP]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-12 production [IDA]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of dendritic cell chemotaxis [IMP]
- positive regulation of mitochondrial translation [ISS]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- positive regulation of trophoblast cell migration [IMP]
- regulation of complement activation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.
The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic integrity by responding to DNA damage through posttranslational modification and coordinating the downstream transcriptional response. We demonstrate that genotoxic stress stimulates Cry1 phosphorylation and ... [more]
Elife Mar. 11, 2015; 4(0); [Pubmed: 25756610]
Throughput
- High Throughput
Curated By
- BioGRID