BAIT
CRY2
HCRY2, PHLL2
cryptochrome circadian clock 2
GO Process (13)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- blue light signaling pathway [NAS]
- circadian regulation of gene expression [ISS]
- circadian rhythm [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- glucose homeostasis [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of phosphoprotein phosphatase activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISS]
- photoreactive repair [IDA]
- regulation of circadian rhythm [ISS]
- regulation of sodium-dependent phosphate transport [IDA]
Gene Ontology Molecular Function- DNA (6-4) photolyase activity [IDA]
- DNA binding [IDA]
- FAD binding [ISS]
- blue light photoreceptor activity [NAS]
- damaged DNA binding [IDA]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- phosphatase binding [IPI]
- protein binding [IPI]
- single-stranded DNA binding [IDA]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- ubiquitin binding [IDA]
- DNA (6-4) photolyase activity [IDA]
- DNA binding [IDA]
- FAD binding [ISS]
- blue light photoreceptor activity [NAS]
- damaged DNA binding [IDA]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- phosphatase binding [IPI]
- protein binding [IPI]
- single-stranded DNA binding [IDA]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- ubiquitin binding [IDA]
Homo sapiens
PREY
YWHAE
14-3-3E, HEL2, KCIP-1, MDCR, MDS
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
GO Process (18)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- hippo signaling [TAS]
- intracellular signal transduction [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- membrane repolarization during cardiac muscle cell action potential [IC]
- mitotic cell cycle [TAS]
- negative regulation of peptidyl-serine dephosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of heart rate by cardiac conduction [IC]
- regulation of heart rate by hormone [NAS]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- substantia nigra development [IEP]
Gene Ontology Molecular Function- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.
The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic integrity by responding to DNA damage through posttranslational modification and coordinating the downstream transcriptional response. We demonstrate that genotoxic stress stimulates Cry1 phosphorylation and ... [more]
Elife Mar. 11, 2015; 4(0); [Pubmed: 25756610]
Throughput
- High Throughput
Curated By
- BioGRID