BAIT
CRY2
HCRY2, PHLL2
cryptochrome circadian clock 2
GO Process (13)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- blue light signaling pathway [NAS]
- circadian regulation of gene expression [ISS]
- circadian rhythm [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- glucose homeostasis [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of phosphoprotein phosphatase activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISS]
- photoreactive repair [IDA]
- regulation of circadian rhythm [ISS]
- regulation of sodium-dependent phosphate transport [IDA]
Gene Ontology Molecular Function- DNA (6-4) photolyase activity [IDA]
- DNA binding [IDA]
- FAD binding [ISS]
- blue light photoreceptor activity [NAS]
- damaged DNA binding [IDA]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- phosphatase binding [IPI]
- protein binding [IPI]
- single-stranded DNA binding [IDA]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- ubiquitin binding [IDA]
- DNA (6-4) photolyase activity [IDA]
- DNA binding [IDA]
- FAD binding [ISS]
- blue light photoreceptor activity [NAS]
- damaged DNA binding [IDA]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- phosphatase binding [IPI]
- protein binding [IPI]
- single-stranded DNA binding [IDA]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- ubiquitin binding [IDA]
Homo sapiens
PREY
CRKL
v-crk avian sarcoma virus CT10 oncogene homolog-like
GO Process (5)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.
The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic integrity by responding to DNA damage through posttranslational modification and coordinating the downstream transcriptional response. We demonstrate that genotoxic stress stimulates Cry1 phosphorylation and ... [more]
Elife Mar. 11, 2015; 4(0); [Pubmed: 25756610]
Throughput
- High Throughput
Curated By
- BioGRID