GNB2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ADRBK1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- activation of phospholipase C activity [TAS]
- cardiac muscle contraction [IMP]
- desensitization of G-protein coupled receptor protein signaling pathway [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of striated muscle contraction [IMP]
- negative regulation of the force of heart contraction by chemical signal [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [ISS]
- positive regulation of catecholamine secretion [ISS]
- receptor internalization [IDA]
- signal transduction [TAS]
- tachykinin receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.
G protein-coupled receptors (GPCRs) comprise the largest family of cell surface receptors, regulate a wide range of physiological processes, and are the major targets of pharmaceutical drugs. Canonical signaling from GPCRs is relayed to intracellular effector proteins by trimeric G proteins, composed of α, β, and γ subunits (Gαβγ). Here, we report that G protein β subunits (Gβ) bind to ... [more]
Throughput
- Low Throughput
Additional Notes
- As part of the CRL4 complex
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GNB2 ADRBK1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3569359 |
Curated By
- BioGRID