GJA1
Gene Ontology Biological Process
- ATP transport [ISO]
- adult heart development [IMP]
- apoptotic process [ISO]
- atrial ventricular junction remodeling [IGI]
- blood vessel morphogenesis [IMP]
- cardiac conduction [IMP]
- cell communication [ISO]
- cell communication by chemical coupling [IDA]
- cell communication by electrical coupling [IDA, ISO]
- cell-cell junction organization [IMP]
- cell-cell signaling [IDA, ISO]
- chronic inflammatory response [ISO]
- embryonic digit morphogenesis [IMP]
- embryonic heart tube development [IMP]
- epicardial cell to mesenchymal cell transition [TAS]
- epithelial cell maturation [IMP]
- establishment of epithelial cell polarity [TAS]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- lens development in camera-type eye [IMP]
- milk ejection [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of wound healing [ISO]
- neuron migration [IMP]
- neuron projection morphogenesis [ISO]
- osteoblast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [ISO]
- positive regulation of cell communication by chemical coupling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glomerular filtration [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of striated muscle tissue development [IMP]
- positive regulation of vasoconstriction [ISO]
- positive regulation of vasodilation [ISO]
- protein oligomerization [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of blood vessel remodeling [TAS]
- regulation of bone mineralization [IMP]
- regulation of bone remodeling [IMP]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
- regulation of tight junction assembly [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [IGI, IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IGI, IMP]
- response to pH [ISO]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [IDA]
- transmembrane transport [IDA, ISO]
- vascular transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- apical plasma membrane [IDA]
- cell junction [IDA]
- cell-cell junction [IDA]
- connexon complex [ISO]
- contractile fiber [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- early endosome [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- intercalated disc [IDA, ISO]
- intermediate filament [IDA]
- late endosome [ISO]
- lateral plasma membrane [IDA]
- lysosome [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- mitochondrial outer membrane [ISO]
- multivesicular body [ISO]
- plasma membrane [IDA, ISO]
EPS15
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes.
GJIC (gap junction intercellular communication) between cardiomyocytes is essential for synchronous heart contraction and relies on Cx (connexin)-containing channels. Increased breakdown of Cx43 has been often associated with various cardiac diseases. However, the mechanisms whereby Cx43 is degraded in ischaemic heart remain unknown. The results obtained in the present study, using both HL-1 cells and organotypic heart cultures, show that ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Curated By
- BioGRID