NTRK1
Gene Ontology Biological Process
- B cell differentiation [ISO]
- Sertoli cell development [IMP]
- aging [IEP]
- axon guidance [IMP]
- axonogenesis involved in innervation [ISO, ISS]
- cellular response to growth factor stimulus [IDA]
- cellular response to nerve growth factor stimulus [IDA]
- cellular response to nicotine [IDA]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- detection of temperature stimulus involved in sensory perception of pain [IMP]
- developmental programmed cell death [IDA]
- learning or memory [IMP]
- mechanoreceptor differentiation [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of neuron death [IDA]
- nerve growth factor signaling pathway [IDA, ISO]
- nervous system development [ISO]
- neurotrophin TRK receptor signaling pathway [ISO, ISS]
- olfactory nerve development [IEP]
- peptidyl-tyrosine phosphorylation [IDA, ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of Ras GTPase activity [ISO, ISS]
- positive regulation of Ras protein signal transduction [ISO, ISS]
- positive regulation of angiogenesis [ISO]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of programmed cell death [IDA]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO, ISS]
- response to activity [IDA]
- response to axon injury [IEP]
- response to drug [IDA]
- response to electrical stimulus [IDA]
- response to ethanol [IEP]
- response to hydrostatic pressure [IEP]
- response to nicotine [IDA]
- response to nutrient levels [IDA]
- response to radiation [IEP]
- sensory perception of pain [IMP]
- sympathetic nervous system development [ISO, ISS]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- kinase binding [IPI]
- nerve growth factor binding [IDA, ISO, ISS]
- nerve growth factor receptor activity [ISO, ISS]
- neurotrophin p75 receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- protein tyrosine kinase activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [ISO, ISS]
- ephrin receptor binding [IPI]
- kinase binding [IPI]
- nerve growth factor binding [IDA, ISO, ISS]
- nerve growth factor receptor activity [ISO, ISS]
- neurotrophin p75 receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- protein tyrosine kinase activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [ISO, ISS]
Gene Ontology Cellular Component
NGFR
Gene Ontology Biological Process
- axon guidance [ISO]
- cellular response to oxidative stress [IMP]
- central nervous system development [ISO]
- circadian regulation of gene expression [ISO, ISS]
- detection of temperature stimulus [ISO]
- glucose homeostasis [ISO, ISS]
- hair follicle morphogenesis [ISO]
- intracellular protein transport [ISO, ISS]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISO]
- negative regulation of hair follicle development [ISO]
- negative regulation of mitochondrial depolarization [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron projection development [IDA]
- nerve development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell death [IDA]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of myelination [IMP]
- positive regulation of neuron death [IDA]
- positive regulation of odontogenesis of dentin-containing tooth [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of synaptic transmission, cholinergic [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- programmed cell death [ISO]
- regulation of gene expression [ISO]
- regulation of glucose import in response to insulin stimulus [ISO, ISS]
- regulation of reactive oxygen species metabolic process [IMP]
- response to lipopolysaccharide [IEP]
- response to wounding [IMP]
- sensory perception of pain [IMP]
- signal transduction [IDA, ISO]
- skeletal muscle cell differentiation [IEP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell [ISO]
- cell surface [ISO]
- clathrin-coated endocytic vesicle [IDA]
- coated vesicle [IDA]
- cytoplasm [IDA, ISO]
- dendrite membrane [IDA]
- external side of plasma membrane [IDA]
- intracellular [ISO]
- membrane raft [IDA]
- neuronal cell body membrane [IDA]
- neuronal postsynaptic density [ISO]
- nuclear envelope [IDA]
- nucleus [IDA]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- rough endoplasmic reticulum [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Amyloid β-abrogated TrkA ubiquitination in PC12 cells analogous to Alzheimer's disease.
Amyloid beta (Aβ) protein is the primary proteinaceous deposit found in the brains of patients with Alzheimer's disease (AD). Evidence suggests that Aβ plays a central role in the development of AD pathology. Here, we show in PC12 cells, Aβ impairs tropomyosin receptor kinase A (TrkA) ubiquitination, phosphorylation, and its association with p75(NTR), p62, and TRAF6 induced by nerve growth ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NTRK1 NGFR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NTRK1 NGFR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NGFR NTRK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID