HSP90AB1
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- regulation of interferon-gamma-mediated signaling pathway [IMP]
- regulation of type I interferon-mediated signaling pathway [IMP]
- response to unfolded protein [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MET
Gene Ontology Biological Process
- axon guidance [TAS]
- branching morphogenesis of an epithelial tube [IMP]
- cell proliferation [TAS]
- cell surface receptor signaling pathway [NAS]
- endothelial cell morphogenesis [IDA]
- negative regulation of hydrogen peroxide-mediated programmed cell death [IMP]
- peptidyl-tyrosine phosphorylation [NAS, TAS]
- positive chemotaxis [IDA]
- positive regulation of endothelial cell chemotaxis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- semaphorin-plexin signaling pathway [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
The two cytosolic/nuclear isoforms of the molecular chaperone HSP90, stress-inducible HSP90α and constitutively expressed HSP90β, fold, assemble and maintain the three-dimensional structure of numerous client proteins. Because many HSP90 clients are important in cancer, several HSP90 inhibitors have been evaluated in the clinic. However, little is known concerning possible unique isoform or conformational preferences of either individual HSP90 clients or ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID