BAIT
ALKBH3
ABH3, DEPC-1, DEPC1, PCA1
alkB, alkylation repair homolog 3 (E. coli)
GO Process (4)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA]
- mitochondrion [IDA]
- nucleoplasm [IDA, TAS]
- nucleus [IDA]
Homo sapiens
PREY
TUBB2A
CDCBM5, TUBB, TUBB2, dJ40E16.7
tubulin, beta 2A class IIa
GO Process (3)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.
Repair of DNA alkylation damage is critical for genomic stability and involves multiple conserved enzymatic pathways. Alkylation damage resistance, which is critical in cancer chemotherapy, depends on the overexpression of alkylation repair proteins. However, the mechanisms responsible for this upregulation are unknown. Here, we show that an OTU domain deubiquitinase, OTUD4, is a positive regulator of ALKBH2 and ALKBH3, two ... [more]
EMBO J. Jun. 12, 2015; 34(12);1687-703 [Pubmed: 25944111]
Throughput
- High Throughput
Curated By
- BioGRID