BAIT
MACROD1
LRP16
MACRO domain containing 1
GO Process (3)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DHX9
DDX9, LKP, NDH2, NDHII, RHA
DEAH (Asp-Glu-Ala-His) box helicase 9
GO Process (10)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IBA, TAS]
- CRD-mediated mRNA stabilization [IMP]
- DNA duplex unwinding [TAS]
- RNA processing [IBA]
- RNA splicing [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- mRNA splicing, via spliceosome [TAS]
- osteoblast differentiation [IDA]
- positive regulation of type I interferon production [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.
The activation of NF-κB has emerged as an important mechanism for the modulation of the response to DNA double-strand breaks (DSBs). The concomitant SUMOylation and phosphorylation of IKKγ by PIASy and ATM, respectively, is a key event in this mechanism. However, the mechanism through which mammalian cells are able to accomplish these IKKγ modifications in a timely and lesion-specific manner ... [more]
Nucleic Acids Res. Mar. 31, 2015; 43(6);3167-79 [Pubmed: 25735744]
Throughput
- Low Throughput
Additional Notes
- Table S1
Curated By
- BioGRID