BAIT

FBXL12

Fbl12
F-box and leucine-rich repeat protein 12
UPS Project
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens
PREY

CAPN1

CANP, CANP1, CANPL1, muCANP, muCL, PIG30
calpain 1, (mu/I) large subunit
Alzheimer's Disease Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.

Nishiyama M, Nita A, Yumimoto K, Nakayama KI

How stem cells maintain their stemness or initiate exit from the stem cell state for differentiation remains largely unknown. Aldehyde dehydrogenase (ALDH) activity is a hallmark of stem cells-including embryonic, adult tissue, and cancer stem cells-and is essential for their maintenance. The mechanisms by which ALDH activity is regulated in stem cells have remained poorly understood, however. We now show ... [more]

Stem Cells Nov. 01, 2015; 33(11);3327-40 [Pubmed: 26124079]

Throughput

  • Low Throughput

Curated By

  • BioGRID