CSNK2A1
Gene Ontology Biological Process
- axon guidance [TAS]
- chaperone-mediated protein folding [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle checkpoint [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein catabolic process [IDA]
- protein phosphorylation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TFAP2A
Gene Ontology Biological Process
- bone morphogenesis [ISS]
- cellular response to iron ion [IDA]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic forelimb morphogenesis [ISS]
- eyelid development in camera-type eye [ISS]
- inner ear morphogenesis [IMP]
- kidney development [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of transcription by competitive promoter binding [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- oculomotor nerve formation [ISS]
- optic cup structural organization [ISS]
- optic vesicle morphogenesis [ISS]
- palate development [IMP]
- positive regulation of bone mineralization [IDA]
- positive regulation of gene expression [ISS]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of tooth mineralization [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of cell differentiation [IDA]
- retina layer formation [IEP]
- sensory perception of sound [IMP]
- transcription from RNA polymerase II promoter [IDA]
- trigeminal nerve development [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISS]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein homodimerization activity [TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISS]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein homodimerization activity [TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
CK2 phosphorylates AP-2α and increases its transcriptional activity.
Transcription factor AP-2α involves in the process of mammalian embryonic development and tumorigenesis. Many studies have shown that AP-2α functions in association with other interacting proteins. In a two-hybrid screening, the regulatory subunit β of protein casein kinase 2 (CK2β) was identified as an interacting protein of AP-2α; we confirmed this interaction using in-vitro GST pull-down and in-vivo co-immunoprecipitation assays; ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID