BAIT
ARFGAP1
Arf GAP1, Arf1gap
ADP-ribosylation factor GTPase activating protein 1
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HSPA4
Hsp110, Hsp70, irp94
heat shock protein 4
GO Process (12)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- chaperone-mediated protein complex assembly [ISO]
- kidney development [IEP]
- negative regulation of DNA binding [IMP]
- negative regulation of apoptotic process [IEP, IMP]
- negative regulation of cell death [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of protein phosphorylation [IMP]
- positive regulation of angiogenesis [IEP]
- positive regulation of gene expression [IMP]
- positive regulation of protein binding [IDA]
- protein import into mitochondrial outer membrane [ISO]
- response to heat [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ARFGAP1 promotes AP-2-dependent endocytosis.
COPI (coat protein I) and the clathrin-AP-2 (adaptor protein 2) complex are well-characterized coat proteins, but a component that is common to these two coats has not been identified. The GTPase-activating protein (GAP) for ADP-ribosylation factor 1 (ARF1), ARFGAP1, is a known component of the COPI complex. Here, we show that distinct regions of ARFGAP1 interact with AP-2 and coatomer ... [more]
Nat. Cell Biol. May. 01, 2011; 13(5);559-67 [Pubmed: 21499258]
Throughput
- Low Throughput
Curated By
- BioGRID