BAIT
GLIS3
ZNF515
GLIS family zinc finger 3
GO Process (3)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
DNAJA1
Hsj2, Nedd7, RP23-135L5.1
DnaJ (Hsp40) homolog, subfamily A, member 1
GO Process (12)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [ISO]
- androgen receptor signaling pathway [IMP]
- negative regulation of JUN kinase activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of protein ubiquitination [ISO]
- positive regulation of apoptotic process [ISO]
- protein localization to mitochondrion [ISO]
- protein refolding [IBA]
- regulation of protein transport [ISO]
- sperm motility [IMP]
- spermatogenesis [IMP]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.
The transcription factor Gli-similar 3 (Glis3) plays a critical role in the generation of pancreatic ss cells and the regulation insulin gene transcription and has been implicated in the development of several pathologies, including type 1 and 2 diabetes and polycystic kidney disease. However, little is known about the proteins and posttranslational modifications that regulate or mediate Glis3 transcriptional activity. ... [more]
PLoS ONE Jul. 07, 2015; 10(7);e0131303 [Pubmed: 26147758]
Throughput
- Low Throughput
Additional Notes
- Table 1
Curated By
- BioGRID