BAIT
WAS
IMD2, SCNX, THC, THC1, WASP
Wiskott-Aldrich syndrome
GO Process (10)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell receptor signaling pathway [TAS]
- actin polymerization or depolymerization [TAS]
- blood coagulation [TAS]
- defense response [TAS]
- epidermis development [TAS]
- immune response [IMP]
- innate immune response [TAS]
- protein complex assembly [TAS]
- regulation of catalytic activity [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SAE1
AOS1, HSPC140, SUA1, UBLE1A
SUMO1 activating enzyme subunit 1
GO Process (7)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells.
In Wiskott-Aldrich syndrome (WAS), immunodeficiency and autoimmunity often comanifest, yet how WAS mutations misregulate chromatin-signaling in Thelper (TH) cells favoring development of auto-inflammation over protective immunity is unclear. Previously, we identified an essential promoter-specific, coactivator role of nuclear-WASp in TH1 gene transcription. Here we identify small ubiquitin-related modifier (SUMO)ylation as a novel posttranslational modification of WASp, impairment of which converts ... [more]
Blood Oct. 01, 2015; 126(14);1670-82 [Pubmed: 26261240]
Throughput
- High Throughput
Curated By
- BioGRID