IRF3
Gene Ontology Biological Process
- MDA-5 signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [TAS]
- cytokine-mediated signaling pathway [TAS]
- defense response to virus [ISS]
- innate immune response [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- macrophage apoptotic process [TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of interferon-alpha production [ISS]
- positive regulation of interferon-beta production [ISS, TAS]
- positive regulation of type I interferon production [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
IPO5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus.
This study is designed to examine the cellular functions of human Fas-associated factor 1 (FAF1) containing multiple ubiquitin-related domains. Microarray analyses revealed that interferon-stimulated genes related to the antiviral response are significantly increased in FAF1-knockdown HeLa cells. Silencing FAF1 enhanced the poly(I·C)- and respiratory syncytial virus (RSV)-induced production of type I interferons (IFNs), the target genes of interferon regulator factor ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 7
Curated By
- BioGRID