BAIT
NPHS2
AI790225, PDCN, SRN1
nephrosis 2, podocin
GO Process (1)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NOTCH2
AI853703, N2
notch 2
GO Process (30)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- Notch signaling pathway [IC, TAS]
- atrial septum morphogenesis [ISO]
- bone remodeling [ISO]
- cell cycle arrest [ISO]
- cell fate determination [ISO, TAS]
- cell growth [ISO]
- ciliary body morphogenesis [IMP]
- defense response to bacterium [IMP]
- determination of left/right symmetry [IMP]
- embryonic limb morphogenesis [IGI]
- heart looping [IGI]
- humoral immune response [IGI]
- in utero embryonic development [IMP]
- inflammatory response to antigenic stimulus [IGI]
- interleukin-4 secretion [IGI]
- left/right axis specification [IGI]
- morphogenesis of an epithelial sheet [IMP]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- organ morphogenesis [TAS]
- placenta blood vessel development [IMP]
- placenta development [IMP]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of apoptotic process [IGI]
- positive regulation of cell proliferation [IMP]
- positive regulation of osteoclast differentiation [IDA]
- pulmonary valve morphogenesis [ISO]
- wound healing [IDA]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes. Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is found in neurons required for touch sensitivity. ... [more]
Hum. Mol. Genet. Apr. 01, 2016; 25(7);1328-44 [Pubmed: 26792178]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
- Interactor of FLAG-tagged podocin expressed in podocytes
Curated By
- BioGRID